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Mechanistic studies have revealed that altered expression of iron metabolism-related proteins (including GPX4, FTH1, TfR1, and HO-1), accumulation of lipid peroxidation products, and disruption of antioxidant defense systems (particularly the Nrf2/GPX4 pathway) are central to ferroptosis progression in cardiac tissue

What the Research Record Shows The BPC-157 literature is extensive for an unapproved compound and concentrated: the overwhelming majority of published work originates from a single research group at the University of Zagreb, led by Predrag Sikiric and Sven Seiwerth [11]

Pharmacol Res 176:106083 Wang M, Xing S, Liu Y, An Z, Liu X, Liu T, Zhang H, Dai Y, Yang H, Wang Y (2024) 2-Acetylacteoside improves recovery after ischemic stroke by promoting neurogenesis via the PI3K/Akt pathway