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Longterm systemic data are limited, so professional dosing and monitoring are important

KLOW's mechanism involves modulation of neuroinflammatory cytokines (specifically IL-6 and TNF-alpha downregulation) and BDNF upregulation in hippocampal neurons

All donors gave written informed consent and protocols were approved by the ethical review board of Fundao Hospitalar de Hematologia e Hemoterapia do Amazonas (CAEE: 51257921.2.0000.0009, approval number #4.982.395/2021)

doi:10.1096/fj.202000239RR

The liver is a key organ for endogenous carnitine synthesis and metabolism, and carnitine homeostasis in the liver has a major effect on carnitine levels in other tissues throughout the body [213, 214]