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10.1038/nrneurol.2017.188 Nat

These areas include the lung, brain, liver, pancreas, vascular system, kidneys, and others

Mitochondrial Ca 2+ overload due to MCU overactivation increases Ca 2+ sensitivity, enhancing myosin light chain phosphorylation and promoting contraction, and mitochondrial ROS activate redox-sensitive pathways such as MAPK and NF-B, driving VSMC proliferation and neointima formation