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264,265 Chronic hyperglycemia elevates ROS production through multiple pathways, including enhanced glucose oxidation, activation of NADPH oxidases, and dysfunction of the mitochondrial electron transport chain

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In a systematic review of 10 clinical trials in patients with HIV lipodystrophy, tesamorelin was effective in reducing VAT and increasing lean body mass and did not alter subcutaneous adipose tissue (146), and increased GH and IGF-I while insulin and glucose levels are unchanged indicating preservation of insulin sensitivity (147150) ( Table 1 )

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