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Potential off-target effects, such as promoting cancer, serve as a crucial reminder that even protective pathways have context-dependent effects, echoing the delicate balance of redox signaling versus distress laid out in Section 2.2

4 Moreover, females exhibit a biologically distinct metabolic context from males, shaped by sex-specific physiological programs, including pregnancy and lactation, which involve profound shifts in lipid metabolism and carnitine demand, 8 which remain largely unexplored

MPT facilitates the release of mitochondrial intermembrane proteins, including endonuclease G and apoptosis-inducing factor, both of which translocate to the nucleus

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