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If you develop severe gastrointestinal symptoms upon restarting, contact your provider, as stepping down to a lower dose and re-escalating may be necessary
Should I switch to tirzepatide if semaglutide isnt working
it's prepared per individual prescription and isn't FDA-reviewed for safety, effectiveness, or quality Compounded tirzepatide uses the same active ingredient as Mounjaro and Zepbound but carries the same compounded medication qualification - not FDA-approved as a finished drug product STEP 1 trial (NEJM): 14.9% average body weight loss at 68 weeks with semaglutide 2.4mg - this was the studied FDA-approved formulation in a controlled trial setting
When researchers went back through semaglutide trial data and separated results by sex, women had lost a greater percentage of body weight at the same dose
There was also a significant 26% relative risk reduction in the primary composite outcome (the first occurrence of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke) in the semaglutide group compared to the placebo group
