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This leads to the accumulation of lipid peroxides, which are oxidized by ferrous ions (Fe 2+ ) in a Fenton-like reaction, generating excessive ROS and ultimately triggering ferroptotic cell death (Zhang C

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Genes encoding several glycolytic enzymes, such as phosphoglycerate kinase 1, enolase, aldolase A, LDHA, and phosphofructokinase, have been proposed to be direct targets of HIF1 [134,135,136,137,138]