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The STEP trials (the major trials of semaglutide for weight management) included detailed monitoring of psychiatric symptoms

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Shi A, Xie P, Nielsen LL, Skjth TV, He X, Haugaard SP (2021) Pharmacokinetics, safety and tolerability of once-weekly subcutaneous semaglutide in healthy Chinese subjects: a double-blind, phase 1, randomized controlled trial

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demonstrated that semaglutide had similar effects in an ovariectomized rat model, increasing -catenin expression and reducing RANKL production, which resulted in a net increase in bone formation