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We performed a series of PubMed, Medline and Embase databases systemic searches

Semaglutide was removed from the shortage list on February 21, 2025, with grace periods for compounders expiring by May 2025

Despite intensive glycemia control having proven clinical benefits for several outcomes, the residual risk of cardiovascular (CV) death has remained a significant unmet need in patients with T2DM

These medications are highly effective in achieving glycemic control while also promoting beneficial cardiorenal effects and reducing the risk of all-cause mortality

Participants were screened between 1 November 2017 and 17 September 2018