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HRT is widely used to address symptoms such as vasomotor instability, sleep disruption, and bone loss

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To remove the effects of pauses in medication or low average medication dose, several thresholds for MPR were used: MPR 0.5, MPR 0.75, and MPR 0.95

Expired products have been reduced significantly, boosting patient safety and ensuring better compliance

Nonetheless, the interpretation of current data is limited by detection and prescription biases in observational studies as well as insufficient follow-up and number of events in randomized trials