A Phase-3 randomized clinical trial showed that the efficacy of HSK16149 capsules was superior to placebo in all groups for relieving PDPN and appeared well tolerated
In some embodiments, the auris-acceptable penetration enhancer is a surfactant comprising an alkyl-glycoside wherein the alkyl-glycoside comprises a sugar linked to a hydrophobic alkyl (e.g., an alkyl comprising about 6 to about 25 carbon atoms) by an amide linkage, an amine linkage, a carbamate linkage, an ether linkage, a thioether linkage, an ester linkage, a thioester linkage, a glycosidic linkage, a thioglycosidic linkage, and/or a ureide linkage
Health-related statements according to EU Regulation 1924/2006 (approved health claims for the contained nutrients) The following statements are scientifically substantiated for the nutrients contained in Glutathion comp and approved by the European Food Safety Authority (EFSA): Zinc contributes to normal macronutrient metabolism contributes to normal protein synthesis contributes to normal DNA synthesis contributes to normal cognitive function contributes to the normal function of the immune system helps protect cells from oxidative stress has a role in the process of cell division Selenium contributes to the normal function of the immune system contributes to normal thyroid function helps protect cells from oxidative stress Vitamin B1 (Thiamine) contributes to normal energy-yielding metabolism contributes to the normal function of the nervous system contributes to normal psychological function contributes to normal heart function Vitamin B2 (Riboflavin) contributes to normal energy-yielding metabolism contributes to the normal function of the nervous system contributes to normal iron metabolism helps protect cells from oxidative stress contributes to the reduction of tiredness and fatigue Vitamin B3 (Niacin) contributes to normal energy-yielding metabolism contributes to the normal function of the nervous system contributes to normal psychological function contributes to the reduction of tiredness and fatigue Glutathione, AC, Alpha-Lipoic Acid Currently, no specific health claims are approved for these nutrients in the EU regulation
The medication was not withdrawn from sale for reasons of safety or effectiveness
For patients seeking weight loss who request B12 injections, GPs should: Assess for genuine deficiency through appropriate blood tests rather than empirical treatment Provide education about the lack of evidence supporting B12 for weight loss in non-deficient individuals Explore underlying concerns about weight and energy levels, addressing these through appropriate channels Signpost to evidence-based resources such as NHS weight management services according to local pathways Patients should contact their GP if they experience unexplained fatigue, neurological symptoms (numbness, tingling, balance problems), or signs of anaemia (pallor, breathlessness, palpitations), as these may indicate B12 deficiency requiring investigation
