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The experiments on rat model RG2 and in brain-tumorized rats obtained mixed results on drug uptake and toxicity, but remarkably this combination reduced inflammation in the peri-tumoral area ( In vivo orthotopic glioblastoma-bearing rats, treatment with PTX/ETP co-loaded mPEG-PLGA NPs resulted in enhanced antitumor efficacy with significant tumor regression and a long-term survival in 40% of the animals

Because it is not metabolized by the liver like some other cough suppressants, it may be a safer alternative for individuals with liver impairment or those taking multiple medications that could interact adversely

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The triple agonist approach creates what researchers describe as a metabolic triple threat