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Generally, a few hours' variation is acceptable, but significant time differences may require clinical advice

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Equally revealing was the observation that the NADH/NAD couple, which slowly interacts with the GSH system (Rost and Rapoport, 1964), could not substitute for NADPH/NADP in the enzyme-catalyzed system (Rall and Lehninger, 1952), although the redox potentials of the two nucleotide couples are practically identical

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