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In luminal breast cancer, ER/PR positivity is positively correlated with GPX4 expression, while m6A demethylation activates SLC7A11 by inhibiting the FGFR4/GSK-3 pathway, thereby increasing sensitivity to ferroptosis [85]
Women often notice: Increased abdominal fat, even without changes in diet Slower metabolism and reduced calorie burning Increased insulin resistance Loss of muscle mass Persistent hunger and cravings Difficulty sleeping, which further affects weight regulation These changes are rooted in biology, not willpower
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Matrix remodeling
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