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For instance, a high acetyl-CoA/CoA ratio in the mitochondrial matrix inhibits pyruvate dehydrogenase (PDH) that catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA (Pietrocola et al., 2015)

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While subpockets B and C are rather large, subpocket A is narrow and restricted in depth by FAD at the bottom of the pocket, limiting the choice of modifications of the inhibitor in subpocket A