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The specificity of initial antibodies to GLP-1R protein was also controversial

13 ClinicalTrials.govTrial registry search for PE-22-28 / spadin no completed human efficacy trials are listed for this peptide

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"This decision by CBER, which did not identify any safety or efficacy concerns with our product, does not further our shared goal of enhancing America's leadership in developing innovative medicines." - Stphane Bancel, chief executive officer of Moderna Moderna stated in its announcement that the RTF letter contradicts prior written guidance from CBER