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Protocol A is conservative, starting at 1mg and escalating in 4-week blocks

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Given that the first published case report appeared only recently, and that epidemiological studies are still emerging, a label update may follow as more data accumulates

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In stark contrast, Retatrutide intervention induced 373 significant changes relative to the HFD group, with the vast majority (331 metabolites) being significantly down-regulated, and only 42 being up-regulated (Fig