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In non-immune cells, caspase-4 indirectly cleaves pro-IL-18 through conformational changes, amplifying local inflammatory signals (107) Similarly, by promoting the activation of inflammatory vesicles containing NACHT, LRR and PYD domains-containing protein 3 (NLRP3), caspase-11 enhances caspase-1-mediated IL-1 maturation and secretion, forming a synergistic network of classical and non-classical regulatory mechanisms (104)

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Frequent check-ups and blood tests are used to track progress and make any necessary adjustments