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GLP-1 Mechanism Explained GLP-1 medications like semaglutide: Slow digestion Reduce appetite Improve insulin release In simple terms, your brain gets the message: Youre fullstop eating. Dual Action of Tirzepatide Tirzepatide takes it further: GLP-1 reduces appetite GIP improves fat metabolism and insulin response This combo creates a more powerful metabolic effect , which explains why many studies show better results