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Epigenetic and synaptic abnormalities are the most important risk factors in ASD

Consider choosing products with isomer ratios that minimize the proportion of trans 10 cis 12 if possible

A pilot study with metformin supplementation in 21 children and adolescents with PWS showed an improvement of the food-related distress and anxiety, evaluated by hyperphagia questionnaire, but no effects on body weight [19]

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These changes in tissue-specific metabolism underscore the necessity of targeted therapeutics that will help to address the underlying metabolic dysregulation