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MOTS-C is beneficial for a wide range of patients, from those battling metabolic disease to healthy individuals optimizing for longevity

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Currently, the association of 0.05% tretinoin with 4% HQ and 0.01% fluocinolone acetonide (triple combination [TC]) is considered the gold-standard topical treatment for melasma owing to its potent and rapid whitening effect [33, 34]

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