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Fewer critical nodes, particularly below the peptide binding site may suggest that oxyntomodulin has a shorter, therefore quicker, path of communication between the peptide and G protein binding site, relative to GLP-1

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Preclinical research in rodents demonstrated that long-term, high-dose exposure to GLP-1 receptor agonists was associated with thyroid C-cell tumours (medullary thyroid carcinoma)

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