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The findings: no elevated risk of major birth defects compared to unexposed pregnancies

Lancet 397:293304 Rubino F, Nathan DM, Eckel RH et al (2016) Metabolic surgery in the treatment algorithm for type 2 diabetes: a joint statement by international diabetes organizations

Consequently, further clinical studies are required to evaluate the safety, tolerability, and efficacy of mazdutide in adolescents with obesity before its clinical application in this population can be considered

Medical Considerations and Provider Guidance GLP-1 medications are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and should be used cautiously in those with a history of pancreatitis or diabetic retinopathy

Kidney-related complications, including nephrolithiasis and interstitial nephritis, have been reported in comprehensive safety analyses ^36