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Previous non-IgE mediated anaphylactoid reaction does not preclude use in future presentation Monitoring 18 hours after the initiation of the acetylcysteine infusion (2 hours before completion of the second bag), send bloods for: Paracetamol concentration ALT If delayed presentation more than 24 hours post ingestion, also measure: INR Venous blood gas Urea, electrolytes, creatinine (5% of patients with paracetamol toxicity will develop acute renal injury) Consult Poisons Information Centre or clinical toxicologist if continued treatment is required beyond the standard 20 hour course Discontinuation DO NOT cease acetylcysteine early without speaking to the Toxicology team, except in cases of anaphylactoid reactions (see above)
The product must be reconstituted with bacteriostatic water using sterile technique to ensure safety and efficacy
Strategic Procurement Planning for Competitive Advantage Proactive buyers keep an eye on changes in regulations, especially while they wait for EU and FDA decisions on health claim approvals and quality standards
The available pain study was observational
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