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Moreover, CARN was documented to upturn the genetic expression of peroxisome proliferator-activated receptor- coactivator 1-, a well-established crucial regulator of fatty acid oxidation and the Nrf2 gene, and a famous mitochondrial protector via boosting antioxidant levels and controlling mitophagy [20]

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( B ) Schematic of isotope tracing with labeled [ 15 N, 13 C 5 ]valine or [ 13 C 5 ]KIV