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Consideration should be given to the idea that melanin may play a vital role in supplying cellular energy and a significant protective role in diseases anywhere in the body where it is found, providing a unified theory of disease, which extends to cardiovascular disease, cancer, vitiligo, epilepsy/seizures, neuroimmune diseases, neurodegenerative diseases, other diseases of the nervous system, other diseases of the gastrointestinal tract, mast cell diseases, autoimmune diseases, connective tissue disorders, diseases related to adipose tissues, diseases related to epithelial cells, including arteries, veins, capillaries, heart, brain, lungs, and/or muscles, diabetes, diseases involving ears, eyes, nose, and/or skin, and other diseases, disorders, and conditions relating to any form of melanin and/or its precursors, and/or mitochondria ( Table 1 )