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[34] [35] Naltrexone is a competitive, high-affinity antagonist at -opioid receptors and exhibits antagonistic activity at and receptors, occupying the orthosteric binding pocket without producing the conformational change required for downstream G-protein signaling

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However, both medications can cause gastrointestinal side effects, so take ibuprofen with food and use the lowest effective dose for the shortest duration

Completion of the assessment does not establish, and shall not be construed as establishing, a clinicianpatient relationship between the individual completing the assessment ("the User") and the Company

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