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Use of risk prediction equations in earlier stages of disease The working group also considered the need for early identification and intervention in people with high-risk CKD and preserved eGFR (CKD stages G1 to G3) and suggests the use of alternative equations that predict the risk of a 40% decline in eGFR or for kidney failure in this population

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Sometimes this is due to carnitine deficiency caused by valproic acid and other times this is related to the unmasking of a previously unrecognized inborn error of metabolism