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The retrospective cohort study (conducted exclusively by neuro-ophthalmologists with expertise in diagnosing NAION) found that diabetic patients prescribed semaglutide faced a 4.28-fold increased risk of developing NAION compared to those on other diabetes medications while even more concerning, overweight or obese patients using semaglutide for weight loss experienced a staggering 7.64-fold increased risk

What the GLP-1 class data tells us A systematic review published in PMC (2025), analyzing 5 studies encompassing 2,905 adult patients, found significant associations between GLP-1 receptor agonist use and hair loss

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