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[Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people]

Systemic and topical administration work through different pathways, potentially complementing each other

In some embodiments, the auris-acceptable penetration enhancer is a surfactant comprising an alkyl-glycoside wherein the alkyl glycoside is maltose, sucrose, glucose, or a combination thereof linked by a glycosidic linkage to an alkyl chain of 9-16 carbon atoms (e.g., nonyl-, decyl-, dodecyl- and tetradecyl sucroside

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