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Furthermore, the release of DAMPs, such as mtDNA, along with metabolic signals, activates the immune system by serving as potential key triggers for immune activation

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However, there are many more studies that need to be carried out, and the description of ferroptosisa relatively unexplored cancer cell death mechanism that is inhibited by glutathione-dependent GPX4reinforces the importance of cysteine in cancer and points to new perspectives regarding the ways whereby cysteine import and synthesis and glutathione synthesis can be efficiently targeted in order to trigger cell death in cancer

There are systemic factors impacting access to treatment leading to poor outcomes

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