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Of those who could be reached, 14 out of 16 reported subjective improvement in pain

Anal Bioanal Chem 418 , 37493761 (2026)

The risks of unregulated peptide products go beyond the lack of clinical evidence

But beneath the surface of glossy marketing and fitness fantasies lies a far more sobering truth: many of these substances operate in a medical grey zone, with unknown long-term risks, questionable manufacturing standards, and in some cases, life-threatening side-effects

Alternative diagnoses and diagnostic categories include, but are not limited to: Neuromuscular disorders (such as myopathic EDS and Bethlem myopathy) Other heritable connective tissue disorders (such as other types of EDS, LoeysDietz syndrome, Marfan syndrome) Skeletal dysplasias (such as osteogenesis imperfecta) HSD in Adults Adults are diagnosed with HSD if they have symptomatic joint hypermobility that cannot be explained by other conditions