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Note that metformin alone rarely causes hypoglycaemia, but the risk may be higher with sulphonylureas or insulin Medicines metabolised by CYP3A4 or CYP2D6 enzymes : Berberine may inhibit these enzymes, potentially affecting blood levels of many medicines P-glycoprotein substrates : Berberine may affect transport of certain medicines, including some immunosuppressants and cardiac drugs Berberine products should be avoided during pregnancy and breastfeeding due to insufficient safety data

In clinical trials, people lost between 15-21% of their body weight, which is about 30-42 pounds for someone weighing 200 pounds

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If hypoglycemia is severe or doesn't resolve with treatment, call 911 for immediate medical attention