Thus, the enzymes can functionally be considered to be peroxiredoxins (PRX) rather than GPXs (Navrot et al., 2006)
Unlike the simpler AHK tripeptide, the coordinated copper ion in AHK-Cu acts as a critical cofactor for enzymes involved in the cross-linking of collagen and elastin
Following xenobiotic exposure, the Nrf2/Keap1 pathway is activated, releasing Nrf2 and causing it to translocate into the nucleus where it forms a heterodimer with its partner sMAF oncogene homolog
As GGT is a membrane protein, acivicin increases extracellular glutathione levels and decreases glycine-cysteine, which is the source of rate-limiting cysteine in the intracellular synthesis of glutathione (21)
Liu Y, Baba Y, Ishimoto T, Tsutsuki H, Zhang T, Nomoto D, et al