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Opposite results were also found in isolated adult rat cardiomyocytes that contraction was not be accelerated after treated with GLP-1 (107), accompanied with a decreased left ventricular contractility (108)

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4, administration of C10:2 markedly upregulated PCNA, cyclinA, CDK2, Bcl-2, MMP2, MMP9, TGF-, while significantly dowregulated Caspase3 and Bax in PASMCs compared with PDGF-BB group, indicating that C10:2 may promote PASMCs proliferation, apoptosis inhibition and extracellular matrix remodeling in vitro

Enhanced oxidative stress and impaired thioredoxin expression in spontaneously hypertensive rats