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During metastatic evolution, cancer cells exhibit context-dependent metabolic switching, such as the processes of glycolytic metabolism or oxidative phosphorylation of lymph node metastasis or the reliance on fatty acid oxidation to balance the redox of latent brain metastatic cells (183)

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doi: 10.1021/acschemneuro.8b00339 136

Zinc is needed for normal sperm production and function and is concentrated in the prostate gland and semen

In PA or RSL3 exposed cells, we found swollen mitochondria with decreased or vanished cristae, which are specific characteristics of the ferroptosis death [14, 26]