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I have had patients crying in my office as they explained how they used to be so sharp and capable, but now simple daily reminders are a strain

Rather than writing off histamine as a bystander in common allergic reactions, we must consider histamine as a primary agent for various destabilizing effects in the body and a considerable source of systemic stress

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Therefore, the available literature on zonulin as a non-invasive marker for disease characterized by barrier dysfunction should be interpreted with extreme caution