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Medications licensed for type 2 diabetes include: Exenatide (Byetta, Bydureon): Available as twice-daily injections or once-weekly extended-release formulation Liraglutide (Victoza): Administered as a once-daily subcutaneous injection at doses up to 1.8 mg for diabetes Dulaglutide (Trulicity): Once-weekly injection with pre-filled pen devices Semaglutide (Ozempic): Once-weekly injection for diabetes management Oral semaglutide (Rybelsus): The first oral GLP-1 agonist, taken daily For weight management specifically, two formulations have received UK marketing authorisation: Liraglutide 3.0 mg (Saxenda): Licensed for weight management in adults with a BMI 30 kg/m, or 27 kg/m with weight-related comorbidities Semaglutide 2.4 mg (Wegovy): Once-weekly injection approved for chronic weight management under similar BMI criteria It is crucial to understand that whilst these medications demonstrate efficacy in promoting weight loss, they are not specifically indicated for leptin resistance
You should contact your GP or seek specialist referral if you are experiencing: Unexplained weight gain or difficulty losing weight despite lifestyle changes Symptoms that may suggest growth hormone deficiency , such as persistent fatigue, reduced muscle mass, increased abdominal fat, or low mood formal biochemical testing is required before any treatment is initiated Poorly controlled blood glucose or a new diagnosis of type 2 diabetes Interest in weight-management medicines , to discuss licensed options available through NHS or regulated private pathways access to weight-management pharmacotherapy on the NHS is typically via specialist weight management services, subject to local eligibility criteria Seek urgent medical attention via NHS 111 or, if necessary, 999 if you experience severe or persistent abdominal pain (which may indicate pancreatitis), signs of a serious allergic reaction, chest pain or palpitations, or symptoms of diabetic ketoacidosis (extreme thirst, frequent urination, confusion, or vomiting)
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However, berberine did improve blood sugar and cholesterol numbers
