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However, the reduction in HF hospitalisations with semaglutide did not reach statistical significance

Once you settle in at your maintenance dose, gastrointestinal side effects should improve and ultimately go away (although for some people, you may feel mild side effects the day after you give yourself the injection)

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The reason for the difference is that theres "variable absorption when medicines are taken by mouth rather than injected since the gut is different in different people, Azar noted

Refills is not a substitute for in-person medical care