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Increased bile acid biosynthesis is associated with irritable bowel syndrome with diarrhea
Atherogenesis and cardiovascular risk In the presence of risk factors, such as high fat diet and diabetes, GPx1 deficiency was found to augment atherosclerosis in the context of apolipoprotein E deficient mice (GPx1 / ApoE / ) [78, 79]
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Specifically, the peptide downregulates inflammatory genes including interleukin-1, tumor necrosis factor-, and nuclear factor-B, while upregulating protective genes such as those encoding antioxidant enzymes, DNA repair proteins, and extracellular matrix components
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