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In the Electronic Supplementary File (ESF), Table 1 presents the methodology for computing the IRS and CIRS profiles as z unit-based composite scores

Before starting any treatment, you must consult a certified dermatologist or skin specialist to determine the correct dose and the number of sessions required for your specific needs

Individual Metabolism: People's bodies process medications differently, affecting how quickly they notice weight loss

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For instance, *db/db* mice, which lack a functional leptin receptor, and *ob/ob* mice, which are leptin-deficient, are foundational for studying the leptin axis