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Indeed, L-citrulline is known to exert positive effects on exercise performance and recovery (Gonzalez and Trexler 2020)

The connection between diabetes and PD remains unclear, but studies suggest that people with diabetes have up to a 40% higher risk of developing PD, and those with both conditions often experience faster motor symptom progression (4)

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It is increasingly discussed in longevity and preventive-medicine circles as a way to achieve: Metabolic balance without extreme appetite suppression Sustained tolerability by avoiding gastrointestinal side effects Lower cost and simplified maintenance regimens Long-term receptor engagement for cardiometabolic and neuroprotective benefits While this approach remains off-label and under formal investigation, the biological rationale is strong: GLP-1 signaling is not binary but dose-responsive, and even partial activation may influence inflammatory, vascular, and cognitive pathways linked to aging