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What the 2026 List Actually Shows This question: Are peptides approved by the FDA

SURMOUNT-1 Investigators (2022) Retatrutide once weekly for the treatment of obesity

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Semaglutide, a long-acting GLP-1 agonist, exhibited a sustained weight decrease of approximately 15% of body weight in clinical studies, whereas tirzepatide, a combination GIP/GLP-1 agonist, attained a weight loss of up to 22.5% in the SURMOUNT trials [36,37]