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A small clinical trial (N = 82 LOE 1b) in 2013 showed that LC supplementation improved disease indicators and nutritional status in ALS patients with daily supplementation of 1000 mg LC in 40 patients aged 40 to 75 years, while the control group was still given the same amount of placebo [21]

The peroneal nerve function recovered quickly with return of function at one week (2.0) while sural nerve function recovered rather slowly at four weeks (1.0)

It was historically common but has been largely replaced by thinner options

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These are thought to occur because of increased levels of norepinephrine