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For daily antidepressants at steady state, this typically has no clinically meaningful impact on efficacy
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How Vitamin B3 (Niacin) Interacts with Weight-Loss Medications Use caution The honest verdict Worth a conversation with your clinician High-dose niacin (pharmacologic doses of 5002,000+ mg) can raise blood glucose and worsen glycemic control, potentially opposing GLP-1's glucose-lowering effect and causes GI side effects (nausea, vomiting, diarrhea, flushing) that are additive with GLP-1 adverse events