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The need for additional interventions like diet and exercise is one reason why Kahan stops short of calling this drug a game changer

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The allowance for investigators to use all available information (for example, concomitant medication) to assess glycemic category was primarily included to account for scenarios in which glucose-lowering medications were initiated during the trial that would confound glycemic category assessment if based purely on fasting plasma glucose or HbA 1c levels (for example, if a patient developed diabetes during the study and received a glucose-lowering drug that resulted in their glucose level being below the American Diabetes Association threshold for type 2 diabetes diagnosis)

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Semaglutide alleviates pancreatic -cell dysfunction via METTL14 signaling and modulation of the gut microbiota in type 2 diabetes mellitus mice