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These findings suggest that research into the therapeutic modulation of FOXO4 activity, such as through the use of the synthetic peptide FOXO4-DRI, could provide insight into the heart's natural protective mechanisms and degenerative changes associated with aging

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This effect is achieved through the normalization of abnormal tumor vasculature, which could lead to a more uniform drug distribution and reduction of the exposure of cancer cells to the sublethal concentrations of chemotherapeutic agents that may otherwise promote tumor cell proliferation 33,34,35

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2023;175(5):e13992