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For example, a small fraction of individuals on Saxenda reported neuropsychiatric issues, such as suicidal thoughts or behaviour, which did not commonly occur with Wegovy

10.1111/j.17433150.2004.00490.x 44

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People taking semaglutide, the popular medication for diabetes and weight loss, are more likely to report having thoughts of suicide compared with those taking other drugs, according to a new study of an international drug safety database

The discrepancy between peripheral and central administration of PYY on food intake has not been explained, but Batterham et al (72) proposed that it may be due to the activation by this peptide of Y2 receptors in hypothalamic ARC neurons where the blood-brain barrier is relatively permeable