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An open-label study (n=42) found that IV NAC (50 mg/kg) combined with oral NAC (500 mg twice daily) for 3 months increased brain glutathione levels (measured by MRS), increased dopamine transporter binding (measured by DaTscan), and improved UPDRS motor scores (Monti et al., PLoS One, 2016) [53]

10.1016/j.freeradbiomed.2023.12.047 195 ZhouR.FuW.VasylyevD.WaxmanS

This dying-back pattern of degeneration emphasizes long axons increased metabolic and transport sensitivity, highlighting axonal pathology as an initial and crucial event in PD development [11, 12]

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Andriollo-Sanchez et al., 2005)