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Clinical trials paint a clear picture: those using semaglutide consistently experience more significant weight loss than those on placebo or other weight loss medications

While current evidence suggests beneficial effects, the complex role of GIP in energy metabolism could potentially lead to unexpected consequences with extended exposure

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151 Other investigators suggested that inactivation of AAT by oxidation of either Met-351 or Met-358 provides a mechanism for regulation of its activity at sites of inflammation

Heard et al., 2014